Molecular determinants involved in activation of caspase 7
نویسندگان
چکیده
منابع مشابه
Molecular determinants involved in activation of caspase 7.
During apoptosis, initiator caspases (8, 9 and 10) activate downstream executioner caspases (3, 6 and 7) by cleaving the IDC (interdomain connector) at two sites. Here, we demonstrate that both activation sites, site 1 and site 2, of caspase 7 are suboptimal for activation by initiator caspases 8 and 9 in cellulo, and in vitro using recombinant proteins and activation kinetics. Indeed, when bot...
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ژورنال
عنوان ژورنال: Bioscience Reports
سال: 2011
ISSN: 0144-8463,1573-4935
DOI: 10.1042/bsr20100111